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In line with the in vivo experimental findings, these data demonstrated that Fsp1 knockout aggravated CaOX-induced mitochondrial damage, intensified lipid peroxidation, and further enhanced ferroptosis in MTECs

Some bacterial metabolites, such as adenosine, 5-methylthioadenosine, sialic acid, tyrosine, and glutathione, are associated with better COPD prognosis

237,238 Several studies using animal models have demonstrated that acute GLP-1 infusion increased heart rate, blood pressure and glucose uptake by the heart, whereas chronic GLP-1R agonism in rodents reduced blood pressure and prevented hypertension

Because it induces pulsatile growth hormone secretion mimicking natural rhythms, timing relative to meals and sleep may influence efficacy and response patterns